Dr Pascal Duijf
|Dr Pascal Duijf|
Cancer cells often missegregate their chromosomes during cell division, or mitosis. This phenomenon is termed chromosome instability. Dr Duijf’s research group focuses on identifying the mechanisms of chromosome instability in cancer cells. His research in this area is aimed at developing new approaches to improve the diagnosis and treatment of cancer.
Dr Duijf first became interested in genetics and cell biology in high school. During chemistry and biology classes, his curiosity was stimulated by the processes of DNA replication, protein synthesis and cell division. In the final year of high school, his class visited a research laboratory at the local university hospital. This environment definitively sparked his fascination for biomedical research. His desire to pursue a career in this field led to his obtaining a Bachelor’s degree in Biology and a Master’s degree in Medical Biology from the Radboud University Nijmegen in the Netherlands.
Subsequently, Dr Duijf successfully applied for two scholarships. Those enabled him to gain research experience in cell biology in Professor Frank McKeon’s laboratory in the department of Cell Biology at Harvard Medical School in the United States.
Phone: +61 7 3443 6937
Vaidyanathan S*, Cato K*, Tang L, Pavey S, Haass NK, Gabrielli BG, Duijf PHG#. In vivo overexpression of Emi1 promotes chromosome instability and tumorigenesis. (2016) Oncogene, in press. PMID: 27065322.
* Equal first authors, # Corresponding author
Vaidyanathan S, Thangavelu PU, Duijf PHG#. Overexpression of Ran GTPase components regulating nuclear export, but not mitotic spindle assembly, marks chromosome instability and poor prognosis in breast cancer. (2016) Target Oncol, in press. PMID: 27023921
# Corresponding author
Duijf PHG#, Benezra R#. The cancer biology of whole-chromosome instability. (2013) Oncogene 32(40): 4727-4736. PMID: 23318433. # Corresponding author
Cancer cells frequently missegregate their chromosomes during cell division. This phenomenon, termed chromosome instability, leads to the formation of aneuploid cells, i.e., cells with abnormal chromosome numbers. Chromosome instability is one of the most malignant features of cancer cells, because it can cause cancer, it accelerates cancer progression and it is an important mechanism for cancer cells to become resistant to cancer therapies.
- The cancer biology of chromosome instability in mouse models
- Identification of pathways that cause chromosome instability/aneuploidy
- Transcriptional regulation of cell cycle genes
- Development of strategies to specifically target aneuploid tumour cells