Dr James Wells
|Dr James Wells|
Wells enrolled as a Zoology undergraduate at the University of Edinburgh, but soon switched to Immunology, and a project during his honours year roused a strong interest in dendritic cells (DCs). Part of the early immune response to infection, DCs intercept intruders such as viruses or bacteria, then teach other immune cells to recognise and attack them.
Moyle, Peter M., Dai, Wei, Liu, Tzu-Yu, Hussein, Waleed M., Maruthayanar, Pirashanthini, Wells, James W., McMillan, Nigel A. J., Skwarczynski, Mariusz and Toth, Istvan (2015) Combined synthetic and recombinant techniques for the development of lipoprotein-based, self-adjuvanting vaccines targeting human papillomavirus type-16 associated tumors. Bioorganic and Medicinal Chemistry Letters, 25 23: 5570-5575. doi:10.1016/j.bmcl.2015.10.049
Collin, Joseph F., Wells, James W., Czepulkowski, Barbara, Lyne, Linden, Duriez, Patrick J., Banham, Alison H., Mufti, Ghulam J. and Guinn, Barbara-ann (2015) A novel zinc finger gene, ZNF465, is inappropriately expressed in acute myeloid leukaemia cells. Genes Chromosomes Cancer, 54 5: 288-302.
Jung, Ji-Won, Overgaard, Nana H., Burke, Michael T., Isbel, Nicole, Frazer, Ian H., Simpson, Fiona and Wells, James W. (2015) Does the nature of residual immune function explain the differential risk of non-melanoma skin cancer development in immunosuppressed organ transplant recipients?. International Journal of Cancer,
Bergot, Anne-Sophie, Monnet, Nastasia, Tran, Son Le, Mittal, Deepak, Al-Kouba, Jane, Steptoe, Raymond J., Grimbaldeston, Michele A., Frazer, Ian H. and Wells, James W. (2015) HPV16 E7 expression in skin induces TSLP secretion, type 2 ILC infiltration and atopic dermatitis-like lesions. Immunology and Cell Biology, 93 6: 540-547.
Overgaard, Nana H., Jung, Ji-Won, Steptoe, Raymond J. and Wells, James W. (2015) CD4+/CD8+ double positive T cells: more than just a developmental stage?. Journal of Leukocyte Biology, 97 1: 31-38.
Burke, Michael T., Isbel, Nicole, Barraclough, Katherine A., Jung, Ji-Won, Wells, James W. and Staatz, Christine E. (2015) Genetics and nonmelanoma skin cancer in kidney transplant recipients. Pharmacogenomics, 16 2: 161-172.
Freeman, Andrew, Bridge, Jennifer A., Maruthayanar, Pirashanthini, Overgaard, Nana H., Jung, Ji-Won, Simpson, Fiona, Prow, Tarl W., Soyer, H. Peter, Frazer, Ian H., Freeman, Michael and Wells, James W. (2014) Comparative Immune Phenotypic Analysis of Cutaneous Squamous Cell Carcinoma and Intraepidermal Carcinoma in Immune-Competent Individuals: Proportional Representation of CD8+ T-Cells but Not FoxP3+ Regulatory T-Cells Is Associated with Disease Stage. PLoS One, 9 10: e110928.1-e110928.9.
Bergot, Anne-Sophie, Ford, Neill, Leggatt, Graham R., Wells, James W., Frazer, Ian H. and Grimbaldeston, Michele A. (2014) HPV16-E7 expression in squamous epithelium creates a local immune suppressive environment via CCL2- and CCL5- mediated recruitment of mast cells. PLoS Pathogens, 10 10: 1-11.
The laboratory is interested in understanding the immunopathology of Squamous Cell Carcinoma and novel factors that regulate CD8 T-cell function in the skin. We are also interested in understanding how immunosuppressive drugs lead to tumour formation and affect naïve and memory T-cell function in other contexts, such as skin immunity and bone healing. There are 8 major research themes in the laboratory.
- Novel pathways of CD8 T-cell regulation in the skin
- The role of CD4/CD8 double-positive T-cells in skin immunity
- The contribution of T-cell suppression to Squamous Cell Carcinoma development
- The impact of T-cell suppression on bone healing
- The testing of novel therapeutic compounds on Squamous Cell Carcinoma growth and survival
- The impact of immunosuppression on T-cell residency in human skin
- The role of chemokines in the advancement of Squamous Cell Carcinoma
- Novel strategies to improve antibody-based therapies for cancer
2011-2016: Perpetual Trustees Fellowship. James Wells. $1000K.
2014-2015: Cancer Council Queensland. JW Wells, IH Frazer. AP1069748. Chemokine involvement in the differential response of actinic Keratosis and Squamous Cell Carcinoma to Imiquimod therapy. $200K.
2015-2017: ARC Discovery Project Grant. JW Wells, RJ Steptoe, IH Frazer. DP150103714. Deciphering novel control mechanisms in the skin. $464K.