Associate Professor Ray Steptoe
|Dr Ray Steptoe|
Associate Professor Ray Steptoe was always interested in science, and began playing with microscopes at age 10. His natural affinity for science eventually led him to study anatomy and human biology at the University of Western Australia (UWA), but he soon realised that learning established knowledge wasn’t enough. He wanted to also generate new scientific knowledge. A PhD in immunology presented the perfect challenge. He found the role of Dendritic Cells (DCs) in the eye particularly interesting.
DCs are part of the immune system’s early response to invasion. They engulf intruders, like bacteria or viruses, and break them down into small parts, called antigens. The DC then presents the antigens on its surface, and uses them to alert the rest of the immune system, primarily via ‘T-cell’ activation. Killer T cells in particular recognise and destroy invaders, while memory T-cells persist after an infection and help maintain immune memory of those specific antigens.
Telephone: +61 7 3443 6959
10 Recent Publications
Roufaiel, Marian Nassef Kadry Naguib, Wells, James W. and Steptoe, Raymond J. (2015) Impaired T-cell function in B-cell lymphoma: a direct consequence of events at the immunological synapse?. Frontiers in Immunology, 6 JUN: 258.1-258.10. doi:10.3389/fimmu.2015.00258
Foo, Shen Yun, Zhang, Vivian, Lalwani, Amit, Lynch, Jason P., Zhuang, Aowen, Lam, Chuan En, Foster, Paul S., King, Cecile, Steptoe, Raymond J., Mazzone, Stuart B., Sly, Peter D. and Phipps, Simon (2015) Regulatory T cells prevent inducible BALT formation by dampening neutrophilic inflammation. Journal of Immunology, 194 9: 4567-4576. doi:10.4049/jimmunol.1400909
Blake, Stephen J. P., Ching, Alan L. H., Kenna, Tony J., Galea, Ryan, Large, Justin, Yagita, Hideo and Steptoe, Raymond J. (2015) Blockade of PD-1/PD-L1 promotes adoptive T-Cell immunotherapy in a tolerogenic environment. PLoS One, 10 3: . doi:10.1371/journal.pone.0119483
Bergot, Anne-Sophie, Monnet, Nastasia, Tran, Son Le, Mittal, Deepak, Al-Kouba, Jane, Steptoe, Raymond J., Grimbaldeston, Michele A., Frazer, Ian H. and Wells, James W. (2015) HPV16 E7 expression in skin induces TSLP secretion, type 2 ILC infiltration and atopic dermatitis-like lesions. Immunology and Cell Biology, 93 6: 540-547. doi:10.1038/icb.2014.123
Overgaard, Nana H., Jung, Ji-Won, Steptoe, Raymond J. and Wells, James W. (2015) CD4+/CD8+ double positive T cells: more than just a developmental stage?. Journal of Leukocyte Biology, 97 1: 31-38. doi:10.1189/jlb.1RU0814-382
Shah, Neha D., Parekh, Harendra S. and Steptoe, Raymond J. (2014) Asymmetric peptide dendrimers are effective linkers for antibody-mediated delivery of diverse payloads to B cells in vitro and in vivo. Pharmaceutical Research, Online First 11: 3150-3160. doi:10.1007/s11095-014-1408-1
McNally, Alice, McNally, Michael, Galea, Ryan, Thomas, Ranjeny and Steptoe, Raymond J. (2014) Immunogenic, but not steady-state, antigen presentation permits regulatory T-cells to control CD8+T-cell effector differentiation by IL-2 modulation. PloS One, 9 1: . doi:10.1371/journal.pone.0085455
Khairuddin, Norliana, Blake, Stephen J., Firdaus, Farah, Steptoe, Raymond J., Behlke, Mark A., Hertzog, Paul J. and McMillan, Nigel A. J. (2014) In vivo comparison of local versus systemic delivery of immunostimulating siRNA in HPV-driven tumours. Immunology and Cell Biology, 92 2: 156-163. doi:10.1038/icb.2013.75
Forrester, John V., Steptoe, Raymond J., Klaska, Izabela P., Martin-Granados, Cristina, Dua, Harminder S., Degli-Esposti, Mariapia A. and Wikstrom, Matthew E. (2013) Cell-based therapies for ocular inflammation. Progress in Retinal and Eye Research, 35 82-101. doi:10.1016/j.preteyeres.2013.02.002
Coleman, Miranda A., Bridge, Jennifer A., Lane, Steven W., Dixon, Chantelle M., Hill, Geoffrey R., Wells, James W., Thomas, Ranjeny and Steptoe, Raymond J. (2013) Tolerance induction with gene-modified stem cells and immune-preserving conditioning in primed mice: restricting antigen to differentiated antigen-presenting cells permits efficacy. Blood, 121 6: 1049-1058. doi:10.1182/blood-2012-06-434100
- Wilson NS, Behrens GMN, Lundie RJ, Smith CM, Waithman J, Young L, Forehan SP, Mount A, Steptoe RJ, Shortman KD, de Koning-Ward T, Belz GT, Carbone FR, Crabb BS, Heath WR, Villadangos JA. Systemic activation of dendritic cells by TLR ligands or malaria infection impairs cross-presentation and anti-viral immunity. Nat Immunol. 7:165-172, 2006.
- Steptoe RJ, Ritchie JM, Harrison LC. Transfer of hematopoietic stem cells encoding an autoantigen prevents autoimmune diabetes. J Clin Invest. 111:1357-1363, 2003.
Dr Steptoe’s research interests are aimed at determining the cellular and molecular pathways that are important in determining the fate of T-cell activation. In particular, studies are directed at understanding how to terminate pathogenic T cell responses with the goal of developing new therapeutic approaches to prevent or treat autoimmune diseases.
- Cellular and molecular pathways of T-cell tolerance
- Prevention and reversal of autoimmune diabetes
- Novel methods of gene delivery for tolerance
- Immunotherapy of allergies and anaphylaxis