Cancer

Name Project Details Contact
Dr Andrew Brooks
  • Understanding the mechanism of cytokine receptor activation
  • Understanding the mechanism of the JAK2 kinase activation
  • How mutations in cytokine receptor signalling pathways contribute to cancer
Phone
+61 7 3443 7071
Email
Dr Pascal Duijf
  • The cancer biology of chromosome instability in a transgenic mouse model
  • Identification of pathways that cause chromosome instability/aneuploidy
  • Transcriptional regulation of cell cycle genes
  • Development of strategies to specifically target aneuploid tumour cells
Phone
+61 7 3443 6937
Email
Professor Ian Frazer
  • Immunoregulation in skin and skin cancer
  • Immunotherapy for HPV associated infections
  • Novel approaches to immunisation
Phone
+61 7 3443 8042
Email
i.frazer@uq.edu.au
Professor Maher Gandhi
  • Novel regulators of cellular immunity in Diffuse Large B-cell Lymphoma
  • The interaction between environmental and genetic factors in Hodgkin lymphoma
  • Prognostic and disease response biomarkers
  • Mechanisms of action of immune effector cells
  • The development and characterization of a novel laboratory model of B-cell differentiation and lymphomagenesis.

Phone
+61 7 3443 8026
Email
m.gandhi@uq.edu.au

Associate Professor Nikolas Haass
  • Targeting the actin cytoskeleton as a strategy for melanoma therapy
  • Disarming Tumor Escape Mechanisms in Human Melanoma With Epigenetic Modifiers
  • Real-time cell cycle imaging of melanoma cells in vitro and in vivo
  • Defining the role of Microphthalmia-associated Transcription Factor (MITF) in melanoma growth by real-time cell cycle imaging
Phone
+61 7 3443 7087
Email
n.haass1@uq.edu.au
Dr Michelle Hill
  • Cancer microvesicles as a source of biomarkers and novel target of anti-cancer therapy
  • Systems biology approach to understand lipid raft and caveolin function in health and disease
Phone
+61 7 3443 7049
Email
m.hill2@uq.edu.au
Dr Graham Leggatt
  • Trafficking of T cells to cancerous skin
  • Immunotherapy of skin tumours after lymphodepletion
  • T cell function in normal and cancerous skin tissue
Phone
+61 7 3443 6961
Email
g.leggatt@uq.edu.au
Professor Kiarash Khosrotehrani
  • Understanding the role of the underlying dermis in the genesis and progression of basal cell carcinoma
  • Study of epidermal clonal progression towards cancer.
  • Tumour heterogeneity towards metastasis
  • To understand differences between basal cell carcinoma subtypes at the genomic, transcriptomic and proteomic level
Phone
+61 7 3443 7088 (UQDI)
+61 7 3346 6077 (UQCCR)
Email
k.khosrotehrani@uq.edu.au
Dr Stephen Mattarollo
  • NKT cell immune adjuvant-based therapeutic vaccination in a mouse model of B cell lymphoma.
  • Combination immunotherapies against haematological malignancies.
  • Mechanisms of tumor resistance against immune-based therapies.
  • Susceptibility of autoimmune-prone mice to tumor development.
  • Impact of endocytosis inhibitors on monoclonal antibody-based immunotherapeutics against cancer.
  • Localized immune suppressive mechanisms in HPV-associated pre-cancers.
Phone:
+61 7 3443 6985
Email
s.mattarollo@uq.edu.au
Associate Professor Nicholas Saunders   
  • Understanding the molecular basis for the control of squamous differentiation
  • Understanding how these processes are dysregulated during the development of oral and skin cancers
  • Exploiting this knowledge in the development of novel
    treatments for skin cancers and oral cancer
  • Interrogating chemotherapeutic sensitivity
  • Identifying novel strategies to treat metastatic osteosarcoma
Phone
+61 7 3443 7091
Email
nsaunders@uq.edu.au 
Dr Linda Scott 
  • Molecular pathogenesis and clonal evolution of the myeloproliferative neoplasms
  • Role of dysregulated JAK/STAT signalling in hematologic malignancies
  • Epigenetic regulation in normal hematopoietic stem cells and their malignant equivalents
  • Molecular basis of leukemogenesis
Phone
+61 7 3443 7093
Email
l.scott3@uq.edu.au 
Dr Fiona Simpson
  • Girdin, Daple and Gipie, the HkRP family in trafficking and Oncogenesis
  • Epidermal growth factor trafficking in squamous cell carcinoma and its impact on patient treatment with anti-EGFR inhibitors
Phone
+61 7 3443 6930
Email
f.simpson@uq.edu.au
Dr Chris Slape
  • Novel cell surface protein misexpression in leukaemia
  • Novel transcriptional interactors with nucleoporin proteins
  • Suppression of self-renewal in leukaemia stem cells
Phone: +61 7 344 37074
Email: c.slape@uq.edu.au
Dr Rehan Villani
  • Niche regulation of stem cell behaviour in epidermal skin cancer
Email
r.villani@uq.edu.au
Dr James Wells
  • Uncovering CD8 T-cell control mechanisms in the skin
  • Immunotherapy for the treatment of established skin cancer
  • Requirements for the initiation and treatment of Non-Melanoma skin cancer
  • Immunophenotyping squamous skin cancer
  • Investigating the cytokine microenvironment of squamous cell carcinoma and its precursor lesions
Phone
+61 7 3443 6983
Email
j.wells3@uq.edu.au
Dr Edwige Roy
  • Understanding tumour environment in basal cell carcinoma.
  • Tracking epidermal clonal evolution during skin cancer induction and development using the rainbow technology.
  • Deriving endothelial progenitor cells (EPC) in the treatment of ischemic vascular disease.
     
Phone
+61 7 334 66078
Email
e.roy@uq.edu.au

Autoimmunity

Name Project Details Contact
 
 
 
Dr Antje Blumenthal
  • Innate immune recognition of Mycobacterium tuberculosis and other pathogens
  • Molecular mechanisms of macrophage functions
  • Regulators of immune responses during infection and inflammation
  • Discovery of novel anti-microbials
Phone
+61 3443 6984
Email
a.blumenthal@uq.edu.au
Dr Emma Hamilton-Williams
  • A novel role for the interleukin-2 pathway in humans and mouse models of type 1 diabetes
  • Genetic control of intestinal microflora in type 1 diabetes susceptibility
  • Impaired Regulatory T cell function in type 1 diabetes
Phone
+61 7 3443 6989
Email
e.hamiltonwilliams@uq.edu.au
Assoc Prof Ray Steptoe
  • Exploring T-cell tolerance in B cell malignancies
  • Cellular and molecular pathways of T-cell tolerance
  • Prevention and reversal of autoimmune diabetes
  • Novel methods of gene delivery for tolerance
  • Immunotherapy of allergies and anaphylaxis
Phone
+61 7 3443 6959
Email
r.steptoe@uq.edu.au
Professor Ranjeny Thomas
  • Understanding the molecular control of dendritic cell function in tolerance
  • Pathogenesis of inflammatory bowel disease, psoriasis, uveitis and arthritis in a mouse model of spondyloarthropathy: microbiota and the interaction with host immunity
  • Rheumatoid arthritis antigen-specific therapy: mouse models
  • Antigen-specific T cells in Rheumatoid Arthritis: MHC-peptide interactions with T cells
  • Type 1 (Juvenile) Diabetes novel treatments: mouse models
  • Type 1 diabetes biomarkers: human longitudinal study
Phone
+61 7 3443 6960
Email
ranjeny.thomas@uq.edu.au

Genomics

Name Project Details Contact
Professor David Evans
  • Identifying Causal and Diagnostic Biomarkers in Ankylosing Spondylitis
  • Genome-wide association and next generation sequencing analysis of Osteoporosis and Bone Mineral Density Phenotypes
  • Detecting gene-gene interaction in complex traits and diseases
  • Development of Causal Modelling Approaches in Genome-wide Association Data
  • Epigenetics in complex disease
  • Genome-wide association studies of craniofacial features
Phone
+61 7 3443 7051
Email
d.evans1@uq.edu.au
Dr. Kim-Anh Lê Cao
  • Data integration for biomarker discovery
  • Data integration of longitudinal studies
  • Meta-analysis and cross-platform comparison
  • mixOmics software
  • Microbiome statistical analysis

Phone +61 7 344 37069
Email k.lecao@uq.edu.au 

Dr Alexandre Cristino
  • Computational modelling of gene networks associated with complex diseases
  • Systems-based analysis to identify functional regulatory mutations in neurological disorders
  • Control of microRNA localisation in sub-cellular compartments
  • Deciphering gene networks of immune cells to fight blood cancer
  • Characterisation of microRNA mutation in neurological disorders
  • microRNA function in B-cell differentiation mediated by Epstein-Barr virus
  • microRNA-based therapy for cancer
  • Development of CRISPR/Cas9 technology in cellular model systems

Phone +61 7 344 37979
Email a.cristino@uq.edu.au

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